A meta⁃analysis of caffeine intake at different doses during pregnancy and risk of miscarriage

JIANG Wenbing; ZHANG Wei; CHEN Jianfei; LIU Jun; CHEN Xiaoli

doi:10.14188/j.1671-8852.2024.0123

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A meta⁃analysis of caffeine intake at different doses during pregnancy and risk of miscarriage

更新时间：2026-11-05

- A meta⁃analysis of caffeine intake at different doses during pregnancy and risk of miscarriage
  增强出版
- Medical Journal of Wuhan University Vol. 46, Issue 5, Pages: 670-676(2025)
- 作者机构：
  
  武汉大学护理学院湖北武汉 430071
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2024.0123
  CLC： R714.21
- Received：22 February 2024，
  
  Published：25 May 2025
- 稿件说明：
移动端阅览
姜文兵,章伟,陈建飞等.孕期不同剂量咖啡因摄入与流产风险的Meta分析[J].武汉大学学报（医学版）,2025,46(05):670-676.

JIANG Wenbing,ZHANG Wei,CHEN Jianfei,et al.A meta⁃analysis of caffeine intake at different doses during pregnancy and risk of miscarriage[J].Medical Journal of Wuhan University,2025,46(05):670-676.
姜文兵,章伟,陈建飞等.孕期不同剂量咖啡因摄入与流产风险的Meta分析[J].武汉大学学报（医学版）,2025,46(05):670-676. DOI： 10.14188/j.1671-8852.2024.0123.

JIANG Wenbing,ZHANG Wei,CHEN Jianfei,et al.A meta⁃analysis of caffeine intake at different doses during pregnancy and risk of miscarriage[J].Medical Journal of Wuhan University,2025,46(05):670-676. DOI： 10.14188/j.1671-8852.2024.0123.

摘要

目的

评估孕期咖啡因摄入与流产风险之间的剂量反应关系。

方法

系统检索知网、维普、万方、PubMed、Embase、Web of Science、Cochrane等数据库。2位研究者独立进行文献筛选、文献质量评价和数据提取；进行了分组Meta分析，剂量反应分析。

结果

纳入文献24篇，病例对照研究13篇，队列研究11篇。二分类Meta分析结果显示孕期摄入比不摄入咖啡因的流产风险高39%，即风险比（

）为1.39（95%

：1.29~1.49）。分组后Meta分析显示低剂量组风险相比于无咖啡因摄入组增加19%（95%

：1.09~1.31），中剂量组增加48%（95%

：1.24~1.77），高剂量组增加51%（95%

：1.30~1.76），极高剂量组增加61%(95%

：1.29~1.99）。线性剂量反应Meta分析提示咖啡因摄入每增加100 mg·d

-1

，流产风险增加10%。

结论

流产风险随着孕期咖啡因摄入增加而呈线性增加。

Abstract

Objective

To assess the dose⁃response relationship between caffeine intake during pregnancy and risk of miscarriage.

Methods

The databases of CNKI

VIP

Wanfang

PubMed

Embase

Web of Science

Cochrane

etc.

were searched systematically. Two researchers conducted literature screening

literature quality evaluation

and data extraction independently. Binary and subgroup meta⁃analysis and dose⁃response analysis were performed.

Results

A total of 24 literatures were included

including 13 case⁃control studies and 11 cohort studies. Results of the binary meta⁃analysis showed that caffeine consumption during pregnancy was associated with a 39% higher risk of miscarriage than non⁃caffeine consumption

as risk ratio (

)=1.39 (95%

: 1.29⁃1.49). Meta⁃analysis after grouping showed that the risk increased by 19% (95%

: 1.09⁃1.31) in the low⁃dose group

48% (95%

: 1.24⁃1.77) in the medium⁃dose group

51% (95%

: 1.30⁃1.76) in the high⁃dose group

and 61% (95%

: 1.29⁃1.99) in the very high dose group

respectively

as compared with that of non⁃caffeine consumption group. The dose⁃response curve suggested that for every 100 mg·d⁻¹ increase in caffeine intake

the risk of miscarriage increases by 10%.

Conclusion

The risk of miscarriage increased linearly with increasing caffeine intake during pregnancy.

关键词

Keywords

references

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