Influencing factors of thyroid nodules in healthy population and expression of IGF‑1 as well as its clinical significance in thyroid tissue

PAN Xinyu; CAO Hong; LIANG Jia; LUO Qifan; ZHANG Jingwei; CHEN Fangfang

doi:10.14188/j.1671-8852.2024.0077

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Influencing factors of thyroid nodules in healthy population and expression of IGF‑1 as well as its clinical significance in thyroid tissue

更新时间：2026-11-05

- Influencing factors of thyroid nodules in healthy population and expression of IGF‑1 as well as its clinical significance in thyroid tissue
- Medical Journal of Wuhan University Vol. 46, Issue 6, Pages: 743-748(2025)
- 作者机构：
  
  1.武汉大学中南医院，甲状腺乳腺外科，湖北武汉 430071
  2.武汉大学中南医院，病理科，湖北武汉 430071
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2024.0077
  CLC： R736.1
- Received：29 January 2024，
  
  Published：25 June 2025
- 稿件说明：
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潘欣予,曹宏,梁佳等.健康人群甲状腺结节的影响因素及IGF‑1在甲状腺组织中的表达及临床意义[J].武汉大学学报（医学版）,2025,46(06):743-748.

PAN Xinyu,CAO Hong,LIANG Jia,et al.Influencing factors of thyroid nodules in healthy population and expression of IGF‑1 as well as its clinical significance in thyroid tissue[J].Medical Journal of Wuhan University,2025,46(06):743-748.
潘欣予,曹宏,梁佳等.健康人群甲状腺结节的影响因素及IGF‑1在甲状腺组织中的表达及临床意义[J].武汉大学学报（医学版）,2025,46(06):743-748. DOI： 10.14188/j.1671-8852.2024.0077.

PAN Xinyu,CAO Hong,LIANG Jia,et al.Influencing factors of thyroid nodules in healthy population and expression of IGF‑1 as well as its clinical significance in thyroid tissue[J].Medical Journal of Wuhan University,2025,46(06):743-748. DOI： 10.14188/j.1671-8852.2024.0077.

摘要

目的

分析健康人群中甲状腺结节检出率及相关影响因素，并检测胰岛素样生长因子（IGF‑1）在甲状腺正常组织及病变组织中的表达，探讨甲状腺结节及甲状腺癌的病因机制，为甲状腺疾病的防治提供理论依据。

方法

回顾性收集武汉大学中南医院2019—2022年体检人群的基本信息及体检数据，根据甲状腺超声结果分为结节组和对照组，分析甲状腺结节检出情况，并采用单因素及多因素分析方法对甲状腺结节检出率的相关影响因素进行分析。从检出甲状腺结节的人群中，选择进行了手术治疗、并经病理确诊的20例结节性甲状腺肿患者和20例甲状腺乳头状癌（PTC）患者作为研究对象，分别检测正常甲状腺组织、结节性甲状腺肿、甲状腺癌组织中IGF‑1的表达水平。

结果

在75 324名受检者中，甲状腺结节检出率为60.1%，其中男、女检出率分别为55.3%、67.1%，各年龄组检出率男性均小于女性（

0.05）。女性、高龄、肥胖为甲状腺结节发生的相关影响因素（

0.05）。IGF‑1在结节性甲状腺肿和PTC中的表达均显著高于正常对照组（

0.05），PTC组IGF‑1表达水平显著高于结节性甲状腺肿组（

0.05）。

结论

2019—2022年湖北省地区健康人群的甲状腺结节检出率较高（60.1%），女性、高龄、肥胖是甲状腺结节发生的相关影响因素。IGF‑1对PTC的发生和发展可能起到潜在的相关作用。

Abstract

Objective

To examine the prevalence of thyroid nodules and associated influencing factors among individuals without pre‑existing health conditions

as well as investigate the expression of insulin‑like growth factor 1（IGF‑1） in both normal and malignant nodules. Furthermore

the research seeks to explore the etiology and mechanisms underlying thyroid nodules and thyroid cancer

with the ultimate goal of establishing a theoretical foundation for the prevention and treatment of thyroid diseases.

Methods

The basic information and physical examination data of the health examination population in Zhongnan Hospital of Wuhan University from 2019 to 2022 were retrospectively collected. According to the results of thyroid ultrasound

the patients were divided into the nodule group and the control group. The detection rate of thyroid nodules was analyzed

and the related influencing factors of thyroid nodules detection rate were analyzed by univariate and multivariate analysis methods. Twenty cases of pathologically confirmed nodular goiter and 20 cases of pathologically confirmed papillary thyroid carcinoma (PTC) were selected from the population with thyroid nodules. The expression levels of IGF‑1 in normal thyroid tissues

nodular goiter and thyroid cancer tissues were detected.

Results

Among the 75 324 subjects included

the detection rate of thyroid nodules was 60.1%

with the rates for male and female subjects being 55.3% and 67.1%

respectively. Furthermore

in all age groups

the detection rate for males was lower than that for females (

0.05). Female

old age and obesity were related influencing factors for thyroid nodules (

0.05). The expression of IGF‑1 in nodular goiter and PTC was significantly higher than that in the normal control group (

0.05). The expression of IGF‑1 in PTC was significantly higher than that in nodular goiter group (

0.05).

Conclusion

From 2019 to 2022

the detection rate of thyroid nodules in the healthy population in Hubei Province was high (60.1%). Female

advanced age and obesity are related influencing factors for the occurrence of thyroid nodules. IGF‑1 may play a potential role in the occurrence and development of PTC.

关键词

Keywords

references

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