Research progress on Chinese medicine monomers targeting NLRP3 inflammasomes to ameliorate preeclampsia

CHEN Tingting; FAN Cuifang

doi:10.14188/j.1671-8852.2024.0064

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Research progress on Chinese medicine monomers targeting NLRP3 inflammasomes to ameliorate preeclampsia

更新时间：2026-11-05

- Research progress on Chinese medicine monomers targeting NLRP3 inflammasomes to ameliorate preeclampsia
- Medical Journal of Wuhan University Vol. 46, Issue 4, Pages: 419-423(2025)
- 作者机构：
  
  武汉大学人民医院产科湖北武汉 430060
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2024.0064
  CLC： R714.7
- Received：24 January 2024，
  
  Published：25 April 2025
- 稿件说明：
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陈婷婷,范翠芳.中药单体通过靶向NLRP3炎症小体改善子痫前期的研究进展[J].武汉大学学报（医学版）,2025,46(04):419-423.

CHEN Tingting,FAN Cuifang.Research progress on Chinese medicine monomers targeting NLRP3 inflammasomes to ameliorate preeclampsia[J].Medical Journal of Wuhan University,2025,46(04):419-423.
陈婷婷,范翠芳.中药单体通过靶向NLRP3炎症小体改善子痫前期的研究进展[J].武汉大学学报（医学版）,2025,46(04):419-423. DOI： 10.14188/j.1671-8852.2024.0064.

CHEN Tingting,FAN Cuifang.Research progress on Chinese medicine monomers targeting NLRP3 inflammasomes to ameliorate preeclampsia[J].Medical Journal of Wuhan University,2025,46(04):419-423. DOI： 10.14188/j.1671-8852.2024.0064.

摘要

子痫前期是伴有多种器官功能障碍的妊娠期并发症，目前认为炎症免疫反应过度激活是促进子痫前期发生和发展发病机制之一，其中NLRP3炎症小体作为炎症反应重要介质可以通过介导细胞焦亡促进IL‑1β、IL‑18等促炎症因子的释放，加剧母体局部或全身炎症水平。中药单体抗炎、抗氧化应激等药理学作用能明显改善子痫前期的病理生理变化，因此本文就中药单体靶向NLRP3炎症小体通路防治子痫前期相关机制进行综述。

Abstract

Preeclampsia is a pregnancy complication characterized by multiple organ dysfunction. The overactivation of the inflammatory immune response is currently considered one of the mechanisms that promotes the occurrence and development of preeclampsia. NLRP3 inflammasomes

as an important mediator of the inflammatory response

can trigger pyroptosis. The release of pro⁃inflammatory factors such as IL⁃1β and IL⁃18 worsens local or systemic inflammation and accelerates the progression of preeclampsia. Chinese medicine monomers

with their pharmacological effects of anti-inflammation and antioxidant stress

can significantly improve the pathological and physiological changes of preeclampsia. Therefore

this article reviews the relevant mechanisms of Chinese medicine monomers targeting the NLRP3 inflammasome pathway in the prevention and treatment of preeclampsia.

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Keywords

references

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