Risk assessment value of Lp‑PLA2, sdLDL and Hcy in coronary heart disease and its severity

YUE Xiaole; LI Weiwei; ZHAO Dandan; LI Wanqiu; WANG Siyu; ZHANG Ying; JI Xin

doi:10.14188/j.1671-8852.2024.0058

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Risk assessment value of Lp‑PLA2, sdLDL and Hcy in coronary heart disease and its severity

更新时间：2026-11-05

- Risk assessment value of Lp‑PLA2, sdLDL and Hcy in coronary heart disease and its severity
- Medical Journal of Wuhan University Vol. 46, Issue 7, Pages: 890-894(2025)
- 作者机构：
  
  1.河北医科大学第二医院检验科河北石家庄 050000
  2.南方科技大学医院检验科广东深圳 518055
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2024.0058
  CLC： R541.4
- Received：22 January 2024，
  
  Published：25 July 2025
- 稿件说明：
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岳晓乐,李薇薇,赵丹丹等.Lp‑PLA2、sdLDL及Hcy对冠心病及严重程度的评估价值[J].武汉大学学报（医学版）,2025,46(07):890-894.

YUE Xiaole,LI Weiwei,ZHAO Dandan,et al.Risk assessment value of Lp‑PLA2, sdLDL and Hcy in coronary heart disease and its severity[J].Medical Journal of Wuhan University,2025,46(07):890-894.
岳晓乐,李薇薇,赵丹丹等.Lp‑PLA2、sdLDL及Hcy对冠心病及严重程度的评估价值[J].武汉大学学报（医学版）,2025,46(07):890-894. DOI： 10.14188/j.1671-8852.2024.0058.

YUE Xiaole,LI Weiwei,ZHAO Dandan,et al.Risk assessment value of Lp‑PLA2, sdLDL and Hcy in coronary heart disease and its severity[J].Medical Journal of Wuhan University,2025,46(07):890-894. DOI： 10.14188/j.1671-8852.2024.0058.

摘要

目的

研究脂蛋白相关磷脂酶A2(Lp‑PLA2)、小而密低密度脂蛋白(sdLDL)及同型半胱氨酸(Hcy)对冠心病(CHD)及严重程度的联合风险评估。

方法

回顾性选择2020年12月—2022年6月在河北医科大学第二医院进行冠状动脉（冠脉）造影检查的195例患者作为研究对象，将符合CHD诊断标准的121例患者作为CHD组，不符合CHD诊断标准的74例患者作为对照组。比较两组患者及CHD不同严重程度患者血清Lp‑PLA2、sdLDL及Hcy，采用受试者工作特征曲线(ROC)分析指标对CHD及严重程度的诊断。

结果

CHD组血清Lp‑PLA2、sdLDL及Hcy均高于对照组(均

0.05)，且血清Lp‑PLA2、sdLDL及Hcy对CHD有诊断价值(均

0.05)；与单一指标比，Lp‑PLA2、sdLDL、Hcy联合检测对CHD诊断效能更高，曲线下面积(

AUC

)和特异性均较高。CHD组单支与多支病变血清Lp‑PLA2、sdLDL及Hcy差异无统计意义(均

0.05)，CHD组冠脉重度病变血清Lp‑PLA2、sdLDL及Hcy均高于轻度病变(均

0.05)，且血清Lp‑PLA2、sdLDL及Hcy水平对CHD严重程度有诊断价值(

0.05)；与单一指标比，Lp‑PLA2、sdLDL、Hcy联合检测对CHD严重程度的诊断效能更高，

AUC

和灵敏度均较高。

结论

CHD患者血清Lp‑PLA2、sdLDL及Hcy明显升高，Lp‑PLA2、sdLDL、Hcy联合检测对CHD及严重程度均有诊断价值，三者联合检测或可成为筛查CHD及诊断CHD严重程度的潜在指标。

Abstract

Objective

To study the risk assessment value of lipoprotein‑associated phospholipase A2(Lp‑PLA2)

small dense low‑density lipoprotein (sdLDL) and homocysteine (Hcy) in coronary heart disease(CHD) and its severity.

Methods

A total of 195 patients who underwent coronary angiography in The Second Hospital of Hebei Medical University from December 2020 to June 2022 were selected

including 121 patients who met the diagnostic criteria of CHD (CHD group) and 74 patients who did not meet the diagnostic criteria of CHD (control group). The serum Lp‑PLA2

sdLDL

and Hcy between the two groups

as well as CHD patients with different severity were compared. The receiver operating characteristic (ROC) was used to analyze the diagnostic value of serum indicators for CHD and its severity.

Results

The ser

um Lp‑PLA2

sdLDL and Hcy in the CHD group were higher than those in the control group (

0.05)

and the serum Lp‑PLA2

sdLDL and Hcy had diagnostic value for CHD (

0.05). Compared with a single indicator

Lp‑PLA2+sdLDL+Hcy detection had a higher diagnostic value for CHD

with a higher area under the curve (

AUC

) and specificity. There was no difference in Lp‑PLA2

sdLDL

and Hcy between single and multi⁃vessel lesion(s) subgroups in the CHD group (

0.05). The Lp‑PLA2

sdLDL and Hcy in patients with severe CHD were higher than those in mild CHD (

0.05). The Lp‑PLA2

sdLDL and Hcy had diagnostic value for the severity of CHD (

0.05). Compared with a single indicator

Lp‑PLA2+sdLDL+Hcy detection had a higher diagnostic value for the severity of CHD

with higher

AUC

and sensitivity.

Conclusion

The serum Lp‑PLA2

sdLDL and Hcy in CHD patients are elevated. The Lp‑PLA2+sdLDL+Hcy detection has diagnostic value for CHD and its severity. The Lp‑PLA2+sdLDL+Hcy detection may become a potential indicator for screening and differential diagnosis of CHD and its severity.

关键词

Keywords

references

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