Research progress of stem cell therapy in the treatment of limbal stem cell deficiency

CHEN Chen; YANG Yang

doi:10.14188/j.1671-8852.2024.0002

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Research progress of stem cell therapy in the treatment of limbal stem cell deficiency

更新时间：2026-11-05

- Research progress of stem cell therapy in the treatment of limbal stem cell deficiency
- Medical Journal of Wuhan University Vol. 46, Issue 9, Pages: 1231-1238(2025)
- 作者机构：
  
  武汉大学人民医院眼科中心湖北武汉 430060
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2024.0002
  CLC： R772.2
- Received：02 January 2024，
  
  Published：26 September 2025
- 稿件说明：
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陈晨,杨阳.干细胞疗法在治疗角膜缘干细胞缺乏症中的研究进展[J].武汉大学学报（医学版）,2025,46(09):1231-1238.

CHEN Chen,YANG Yang.Research progress of stem cell therapy in the treatment of limbal stem cell deficiency[J].Medical Journal of Wuhan University,2025,46(09):1231-1238.
陈晨,杨阳.干细胞疗法在治疗角膜缘干细胞缺乏症中的研究进展[J].武汉大学学报（医学版）,2025,46(09):1231-1238. DOI： 10.14188/j.1671-8852.2024.0002.

CHEN Chen,YANG Yang.Research progress of stem cell therapy in the treatment of limbal stem cell deficiency[J].Medical Journal of Wuhan University,2025,46(09):1231-1238. DOI： 10.14188/j.1671-8852.2024.0002.

摘要

角膜缘干细胞缺乏症（LSCD）是由于角膜缘上皮干细胞数量不足或功能障碍而引起的一种病理状态，以复发性上皮缺损、角膜上皮结膜化和新生血管化为主要表现。目前LSCD的治疗策略主要是基于干细胞的修复，根据是否为角膜上皮干细胞来源以及是否为自体来源可以分为不同类型，本文就目前LSCD的治疗方法及其最新研究进展进行了简要综述。

Abstract

Limbal stem cell deficiency (LSCD) is a pathological state caused by insufficient quantity or dysfunction of the limbal epithelial stem cells. LSCD is mainly characterized by recurrent defects

conjunctivalization

and neovascularization in the corneal epithelium. The current treatment strategy is primarily targeted on the restoration of limbal epithelial stem cells. The treatment strategies of LSCD could be classified as different methods according to whether the applied stem cells are derived from limbal epithelial stem cells or from autologous sources. This review provides an overview of different treatment strategies of LSCD and the latest research progress.

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references

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