Research progress of secreted Ly6/uPAR‑related protein 1 in corneal barrier function

MAO Jiewen; WAN Shanshan; YANG Yanning

doi:10.14188/j.1671-8852.2023.0615

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Research progress of secreted Ly6/uPAR‑related protein 1 in corneal barrier function

更新时间：2026-11-05

- Research progress of secreted Ly6/uPAR‑related protein 1 in corneal barrier function
- Medical Journal of Wuhan University Vol. 46, Issue 3, Pages: 397-402(2025)
- 作者机构：
  
  武汉大学人民医院眼科中心湖北武汉 430060
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2023.0615
  CLC： R772.2
- Received：17 November 2023，
  
  Published：25 March 2025
- 稿件说明：
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毛介文,万珊珊,杨燕宁.分泌型Ly6/uPAR相关蛋白1在角膜屏障功能中的研究进展[J].武汉大学学报（医学版）,2025,46(03):397-402.

MAO Jiewen,WAN Shanshan,YANG Yanning.Research progress of secreted Ly6/uPAR‑related protein 1 in corneal barrier function[J].Medical Journal of Wuhan University,2025,46(03):397-402.
毛介文,万珊珊,杨燕宁.分泌型Ly6/uPAR相关蛋白1在角膜屏障功能中的研究进展[J].武汉大学学报（医学版）,2025,46(03):397-402. DOI： 10.14188/j.1671-8852.2023.0615.

MAO Jiewen,WAN Shanshan,YANG Yanning.Research progress of secreted Ly6/uPAR‑related protein 1 in corneal barrier function[J].Medical Journal of Wuhan University,2025,46(03):397-402. DOI： 10.14188/j.1671-8852.2023.0615.

摘要

分泌型Ly6/uPAR相关蛋白1（SLURP1)属于Ly6/uPAR蛋白超家族成员之一，因其独特的三指结构和GPI锚定信号序列的缺乏，且在免疫调节、细胞黏附、信号转导等过程发挥关键作用而受到多学科关注。近年来的研究表明，SLURP1与角膜免疫赦免、角膜新生血管、角膜上皮细胞成熟、角膜上皮细胞间充质转化等密切相关。现就SLURP1在角膜屏障功能中的作用机制研究进行综述，以期为各种角膜病的诊治提供思路。

Abstract

Secretory Ly6/uPAR‑related protein 1(SLURP1) belongs to the Ly6/uPAR protein superfamily. Distinguished by its distinctive three‑finger structure and the absence of a GPI‑anchored signal sequence

SLURP1 plays a key role in immune regulation

cell adhesion

signal transduction and other processes. Recent investigations have shown that SLURP1 is closely related to corneal immune privilege

corneal neovascularization

corneal epithelial cell maturation

and corneal epithelial‑mesenchymal transition. This review delves into the mechanisms by which SLURP1 influences corneal barrier function

aiming to offer insights for the diagnosis and treatment of various corneal diseases.

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Keywords

references

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