Progress in the study of the structure and entry mechanism of the common viral receptor for viral myocarditis in children

ZENG Xiangfan; HUANG Jiyi; DUAN Junkai

doi:10.14188/j.1671-8852.2023.0566

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Progress in the study of the structure and entry mechanism of the common viral receptor for viral myocarditis in children

更新时间：2026-11-05

- Progress in the study of the structure and entry mechanism of the common viral receptor for viral myocarditis in children
- Medical Journal of Wuhan University Vol. 46, Issue 7, Pages: 949-954(2025)
- 作者机构：
  
  1.江西省儿童医院小儿心脏病治疗中心江西南昌 330006
  2.南昌大学医学部江西南昌 330006
  3.江西省卫生健康儿童心血管疾病重点实验室江西南昌 330006
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2023.0566
  CLC： R725.4
- Received：25 October 2023，
  
  Published：25 July 2025
- 稿件说明：
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曾向帆,黄纪毅,段君凯.儿童病毒性心肌炎常见病毒受体结构及进入机制研究进展[J].武汉大学学报（医学版）,2025,46(07):949-954.

ZENG Xiangfan,HUANG Jiyi,DUAN Junkai.Progress in the study of the structure and entry mechanism of the common viral receptor for viral myocarditis in children[J].Medical Journal of Wuhan University,2025,46(07):949-954.
曾向帆,黄纪毅,段君凯.儿童病毒性心肌炎常见病毒受体结构及进入机制研究进展[J].武汉大学学报（医学版）,2025,46(07):949-954. DOI： 10.14188/j.1671-8852.2023.0566.

ZENG Xiangfan,HUANG Jiyi,DUAN Junkai.Progress in the study of the structure and entry mechanism of the common viral receptor for viral myocarditis in children[J].Medical Journal of Wuhan University,2025,46(07):949-954. DOI： 10.14188/j.1671-8852.2023.0566.

摘要

病毒性心肌炎（VMC）是病毒侵犯心肌所致局限性或弥漫性的炎症，目前该病尚无特异性治疗手段。已知30多种病毒易导致VMC，如柯萨奇B组病毒、疱疹病毒、新型冠状病毒及流感病毒等，这些病毒通过血管内皮或心肌细胞表面受体感染机体，造成心脏不同程度受累。柯萨奇B组病毒是VMC最常见的病原体，由心肌细胞表面高度表达的柯萨奇⁃腺病毒受体介导入胞，损伤心肌细胞并激活免疫反应。研究显示，阻碍病毒与受体结合或下调受体表达能直接减少机体感染。近年来，随着病毒与受体结合机制的深入研究，发现了许多新的治疗靶点，本文主要对VMC的常见病毒受体结构及其进入机制研究进展进行综述，旨在为设计抗病毒候选药物和亚单位疫苗提供基础。

Abstract

Viral myocarditis (VMC) is a limited or diffuse inflammation caused by viral invasion of the myocardium

and there is no specific treatment for this disease. More than 30 viruses are known to cause VMC

such as Coxsackie group B viruses

herpesviruses

SARS⁃CoV⁃2

and influenza viruses etc. These viruses infect the body through the endothelium of the blood vessels or the surface receptors of the cardiac myocytes

resulting in varying degrees of cardiac involvement. Coxsackie group B virus

the most common pathogen of VMC

is mediated into the cell by the coxsackie⁃adenovirus receptor

which is highly expressed on the surface of cardiomyocytes

to damage cardiomyocytes and activate immune responses. Studies have shown that impeding viral binding to the receptor or downregulating receptor expression directly reduces infection in the body. In recent years

many new therapeutic targets have been discovered with the development of in⁃depth studies on the mechanisms of virus⁃receptor binding. This article focuses on a review of the progress in the study of the structure of common viral receptors and their entry mechanisms in VMCs to provide a basis for the design of antiviral drug candidates and subunit vaccines.

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references

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