Research progress of machine learning in assistant diagnosis of cardiac amyloidosis

LIANG Yu; QIAO Ruiling; PAN Yuling; ZHANG Shuai; LIANG Chunzi

doi:10.14188/j.1671-8852.2023.0535

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Research progress of machine learning in assistant diagnosis of cardiac amyloidosis

更新时间：2026-11-05

- Research progress of machine learning in assistant diagnosis of cardiac amyloidosis
- Medical Journal of Wuhan University Vol. 46, Issue 6, Pages: 806-811(2025)
- 作者机构：
  
  1.湖北中医药大学检验学院湖北武汉 430065
  2.湖北时珍实验室湖北武汉 430065
  3.中国科学院计算机技术研究所北京 100190
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2023.0535
  CLC： R541
- Received：11 October 2023，
  
  Published：25 June 2025
- 稿件说明：
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梁雨,乔瑞玲,潘雨凌等.机器学习在心脏淀粉样变辅助诊断中的研究进展[J].武汉大学学报（医学版）,2025,46(06):806-811.

LIANG Yu,QIAO Ruiling,PAN Yuling,et al.Research progress of machine learning in assistant diagnosis of cardiac amyloidosis[J].Medical Journal of Wuhan University,2025,46(06):806-811.
梁雨,乔瑞玲,潘雨凌等.机器学习在心脏淀粉样变辅助诊断中的研究进展[J].武汉大学学报（医学版）,2025,46(06):806-811. DOI： 10.14188/j.1671-8852.2023.0535.

LIANG Yu,QIAO Ruiling,PAN Yuling,et al.Research progress of machine learning in assistant diagnosis of cardiac amyloidosis[J].Medical Journal of Wuhan University,2025,46(06):806-811. DOI： 10.14188/j.1671-8852.2023.0535.

摘要

心脏淀粉样变（CA）是一种较为罕见的限制性心肌病，以不溶性淀粉样蛋白异常沉积于心肌间质为主要特征。根据沉积蛋白种类不同，大部分CA被区分为AL和ATTR亚型并制定了相应的诊疗方案。然而，由于CA病情重、进展快、临床识别率低，常规诊断技术极易出现漏诊或延误诊断，使患者失去了早期治疗机会，普遍预后不良。机器学习作为近年来新兴的人工智能技术之一，能够从复杂的原始医学数据中自动量化、提取、分析显著性特征，无需人力先验知识的预处理干预，在临床诊疗决策中显示出先进的诊断性能和应用价值。本文将综述机器学习模型利用不同类型医学数据，在CA诊断预测方面的应用，综合评估其性能、泛化能力和可解释性。

Abstract

Cardiac amyloidosis (CA) is characterized as a relatively uncommon restrictive cardiomyopathy

predominantly identified by the abnormal accumulation of insoluble amyloid proteins in the myocardial interstitium. Based on the category of deposited proteins

a majority of CA patients are differentiated into AL and ATTR subtypes

for which corresponding diagnostic and therapeutic strategies have been developed. Nonetheless

owing to the severity

rapid progression

and low clinical recognition rates of CA

standard diagnostic approaches are prone to overlook or delay diagnosis

depriving patients of early treatment opportunities and generally resulting in poor prognoses. Machine learning

emerging as a novel technology in artificial intelligence in recent years

is capable of automatically quantifying

extracting

and analyzing significant features from complex original medical data without the necessity for human intervention in preprocessing based on prior knowledge

demonstrating advanced diagnostic performance and applicative value in clinical decision‑making. This article will present a comprehensive review of the applications of machine learning diagnostic models based on varying types of medical data in the diagnosis and prediction of CA

conducting a holistic evaluation of their performance

generalizability

and interpretability.

关键词

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references

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