Research progress on the role of SIRT1 in bladder cancer

MA Zhiming; NIE Guoyan; ZHU Mingting; YU Yong; ZHAI Zhenxing

doi:10.14188/j.1671-8852.2023.0477

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Research progress on the role of SIRT1 in bladder cancer

更新时间：2026-11-05

- Research progress on the role of SIRT1 in bladder cancer
- Medical Journal of Wuhan University Vol. 46, Issue 6, Pages: 812-816(2025)
- 作者机构：
  
  1.青海省人民医院泌尿外科青海西宁 810000
  2.兰州大学第二医院泌尿外科研究所甘肃兰州 730030
  3.甘肃省泌尿系统疾病临床医学研究中心甘肃兰州 730030
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2023.0477
  CLC： R737
- Received：03 September 2023，
  
  Published：25 June 2025
- 稿件说明：
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马志明,乜国雁,朱明挺等.SIRT1在膀胱癌中的作用研究进展[J].武汉大学学报（医学版）,2025,46(06):812-816.

MA Zhiming,NIE Guoyan,ZHU Mingting,et al.Research progress on the role of SIRT1 in bladder cancer[J].Medical Journal of Wuhan University,2025,46(06):812-816.
马志明,乜国雁,朱明挺等.SIRT1在膀胱癌中的作用研究进展[J].武汉大学学报（医学版）,2025,46(06):812-816. DOI： 10.14188/j.1671-8852.2023.0477.

MA Zhiming,NIE Guoyan,ZHU Mingting,et al.Research progress on the role of SIRT1 in bladder cancer[J].Medical Journal of Wuhan University,2025,46(06):812-816. DOI： 10.14188/j.1671-8852.2023.0477.

摘要

膀胱癌是严重威胁人类健康的最常见的泌尿生殖系统肿瘤之一。膀胱癌的发生是外界环境因素与内在基因遗传因素共同作用的结果，其具体病因仍不甚明晰，进一步研究其发生发展机制，对于膀胱癌的诊治、预后具有重要意义。沉默信息调节

因子1(SIRT1)为哺乳动物Sirtuins家族成员之一，是一种依赖于烟酰胺腺嘌呤二核苷酸(NAD

)的Ⅲ型组蛋白去乙酰化酶。SIRT1与基因调节、基因组稳定性维持、DNA损伤修复、细胞凋亡、自噬、新陈代谢、增殖、衰老和肿瘤发生密切相关。SIRT1在膀胱癌发生发展中癌基因和抑癌基因的双重作用受到广泛关注，大量SIRT1激动剂和抑制剂的不断发现为膀胱癌的诊治提供了新的方向。本文对SIRT1在膀胱癌中的研究进展做综述。

Abstract

Bladder cancer is one of the most common urogenital tumors

which is a serious threat to human health. The occurrence of bladder cancer is the result of external environmental factors and intrinsic genetic factors. However

its specific etiology is still not well clarified. Further study of its pathogenesis and progression mechanism is significant for the diagnosis

treatment

and prognosis of bladder cancer. Silent information regulator 1 (SIRT1)

a member of the mammalian sirtuins family

is a type Ⅲ histone deacetylase dependent on nicotinamide adenine dinucleotide (NAD

). SIRT1 is closely related to gene regulation

genome stability maintenance

DNA damage repair

cell apoptosis

autophagy

metabolism

proliferation

aging

and tumorigenesis. The dual role of SIRT1 as oncogenes and anti⁃oncogenes in the development of bladder cancer has received extensive attention. The continuous discovery of a large number of SIRT1 agonists and inhibitors has provided a new direction for the diagnosis and treatment of bladder cancer. This article reviews the research progress of SIRT1 in bladder cancer.

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references

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