Effect of transcranial direct current stimulation with different stimulation parameters on patients with minimal disturbance of consciousness after craniocerebral injury

WANG Shanshan; LU Wei; LI Qiaorong; SUN Liang; LIU Min

doi:10.14188/j.1671-8852.2023.0378

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Effect of transcranial direct current stimulation with different stimulation parameters on patients with minimal disturbance of consciousness after craniocerebral injury

更新时间：2026-11-05

- Effect of transcranial direct current stimulation with different stimulation parameters on patients with minimal disturbance of consciousness after craniocerebral injury
- Medical Journal of Wuhan University Vol. 46, Issue 4, Pages: 517-523(2025)
- 作者机构：
  
  山东省立第三医院重症康复科山东济南 250000
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2023.0378
  CLC： R493
- Received：05 July 2023，
  
  Published：25 April 2025
- 稿件说明：
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王珊珊,路伟,李巧荣等.经颅直流电刺激不同刺激参数对颅脑损伤后最小意识障碍患者的疗效[J].武汉大学学报（医学版）,2025,46(04):517-523.

WANG Shanshan,LU Wei,LI Qiaorong,et al.Effect of transcranial direct current stimulation with different stimulation parameters on patients with minimal disturbance of consciousness after craniocerebral injury[J].Medical Journal of Wuhan University,2025,46(04):517-523.
王珊珊,路伟,李巧荣等.经颅直流电刺激不同刺激参数对颅脑损伤后最小意识障碍患者的疗效[J].武汉大学学报（医学版）,2025,46(04):517-523. DOI： 10.14188/j.1671-8852.2023.0378.

WANG Shanshan,LU Wei,LI Qiaorong,et al.Effect of transcranial direct current stimulation with different stimulation parameters on patients with minimal disturbance of consciousness after craniocerebral injury[J].Medical Journal of Wuhan University,2025,46(04):517-523. DOI： 10.14188/j.1671-8852.2023.0378.

摘要

目的

研究应用不同刺激参数经颅直流电刺激治疗颅脑损伤后最小意识障碍患者的临床疗效。

方法

将2020—2022年在山东省立第三医院重症康复科住院的慢性意识障碍患者，按照最小意识障碍（MCS）诊断标准纳入患者，按照随机对照数字表法，分为A组（1 mA，20 min，2 次•d

-1

）19例，B组（2 mA，20 min，2 次•d

-1

）21例，以及C组（假刺激组）20例，共60例患者。3组患者在治疗前以及治疗后第4周以及第8周由固定医师用昏迷恢复修订量表（CRS‑R）进行行为学评估以及脑电图检查。

结果

3组患者治疗前CRS‑R评分以及脑电图评分组间比较差异无统计学意义(

0.05)；治疗后，3组患者CRS‑R评分在治疗后每个时间点与上一个时间点的CRS‑R评分比较差异具有统计学意义（

0.05）；4周治疗后，B组与A组、C组比较差异有统计学意义（

0.05），但是A组与C组比较差异无统计学意义(

0.05)；8周治疗后，3组患者CRS‑R评分同时间点比较，差异具有统计学意义（

0.05）。B组每个时间点与组内前一个时间点的脑电图评分差异有统计学意义（

0.05）。第4周脑电图评分，A组以及C组与治疗前差异无统计学意义（

0.05），B组与C组比较差异有统计学意义(

0.05)。第8周各组脑电图评分与治疗前比较差异有统计学意义（

0.05），各组间比较差异有统计学意义（

0.05）。

结论

经颅直流电刺激可改善最小意识障碍患者的意识状态；2 mA、2 次•d

-1

的刺激参数，治疗最小意识患者的疗效最为明显。

Abstract

Objective

To study the clinical efficacy of transcranial direct current stimulation with different stimulation parameters in patients with minimal consciousness disturbance after brain injury.

Methods

Sixty patients with chronic disorders of consciousness hospitalized in the critical rehabilitation department of Shandong Provincial Third Hospital from 2020 to 2022 were included according to the diagnostic criteria for minimally conscious state (MCS) and were divided into three groups: group A (19 cases; 1 mA

20 min

twice per day)

group B (21 cases; 2 mA

20 min

twice per day)

and group C (20 cases; sham stimulation group). Behavioral assessments using the Coma Recovery Scale⁃Revised (CRS⁃R) and electroencephalogram (EEG) examinations were performed by fixed physicians before treatment and at the 4th and 8th weeks after treatment for all three groups of patients.

Results

There was no significant difference in the CRS⁃R scores and EEG scores before treatment among the three groups (

0.05). After treatment

the differences in CRS⁃R scores between each time point and the previous one within the three groups were statistically significant (

0.05). At 4 weeks after treatment

there was a statistically significant difference between Group B and Groups A and C (

0.05)

but there was no statistically significant difference between Group A and Group C (

0.05). At 8 weeks after treatment

the differences in CRS⁃R scores among the three groups were statistically significant (

0.05). There were statistically significant differences in EEG scores between each time point and the previous one within Group B (

0.05). There were no statistically s

ignificant differences in EEG scores between Group A and Group C at 4 weeks after treatment compared with baseline (

0.05)

but there was a statistically significant difference between Group B and Group C (

0.05). At 8 weeks after treatment

the EEG scores of all groups were statistically significantly different from baseline (

0.05)

and there were statistically significant differences among the groups (

0.05).

Conclusion

Transcranial direct current stimulation can improve the state of consciousness in patients with a MCS. Stimulation parameters of 2 mA applied twice daily were found to be most effective in patients with a MCS.

关键词

Keywords

references

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