Correlation analysis between serum SDF‑1, MMP 3, IL‑1β and grade of intervertebral disc degeneration in patients with lumbar disc herniation

QIN Yuxi; FAN Mingyu

doi:10.14188/j.1671-8852.2023.0161

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Correlation analysis between serum SDF‑1, MMP 3, IL‑1β and grade of intervertebral disc degeneration in patients with lumbar disc herniation

更新时间：2026-11-05

- Correlation analysis between serum SDF‑1, MMP 3, IL‑1β and grade of intervertebral disc degeneration in patients with lumbar disc herniation
- Medical Journal of Wuhan University Vol. 46, Issue 3, Pages: 381-386(2025)
- 作者机构：
  
  1.武汉市第三医院，医务部，湖北武汉 430060
  2.武汉市第三医院，骨一科，湖北武汉 430060
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2023.0161
  CLC： R681.53
- Received：12 March 2023，
  
  Published：25 March 2025
- 稿件说明：
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覃玉曦,范明宇.腰椎间盘突出症患者血清SDF‑1、MMP3、IL‑1β水平与椎间盘退变分级的相关性分析[J].武汉大学学报（医学版）,2025,46(03):381-386.

QIN Yuxi,FAN Mingyu.Correlation analysis between serum SDF‑1, MMP 3, IL‑1β and grade of intervertebral disc degeneration in patients with lumbar disc herniation[J].Medical Journal of Wuhan University,2025,46(03):381-386.
覃玉曦,范明宇.腰椎间盘突出症患者血清SDF‑1、MMP3、IL‑1β水平与椎间盘退变分级的相关性分析[J].武汉大学学报（医学版）,2025,46(03):381-386. DOI： 10.14188/j.1671-8852.2023.0161.

QIN Yuxi,FAN Mingyu.Correlation analysis between serum SDF‑1, MMP 3, IL‑1β and grade of intervertebral disc degeneration in patients with lumbar disc herniation[J].Medical Journal of Wuhan University,2025,46(03):381-386. DOI： 10.14188/j.1671-8852.2023.0161.

摘要

目的

探讨血清基质细胞衍生因子（SDF‑1）、基质金属蛋白酶‑3（MMP3）、白细胞介素‑1β（IL‑1β）与腰椎间盘突出症（LDH）患者椎间盘退变分级的相关性。

方法

选取2020年7月至2022年7月武汉市第三医院收治的LDH患者150例作为观察组，另选同期90例体检为正常椎间盘组织作为健康对照组；对比两组血清SDF‑1、MMP3、IL‑1β表达水平；参照Pfirrmann分级标准将观察组患者分为椎间盘退变Ⅲ级、Ⅳ级、Ⅴ级，对比L4/5、L5/S1节段椎间盘退变不同级别的血清SDF‑1、MMP3、IL‑1β表达水平，并采用Spearman相关性分析方法分析血清SDF‑1、MMP3、IL‑1β表达水平与L4/5、L5/S1节段椎间盘退变分级的相关性。

结果

观察组血清SDF‑1、MMP3、IL‑1β水平均高于对照组（

0.05）。L4/5、L5/S1节段不同腰椎间盘分级椎间盘突出症患者各亚组血清中SDF‑1、MMP3、IL‑1β水平随着病变程度增加而升高（分别为

=68.867、47.578、212.079和

=221.461、346.920、514.849；

0.05）。Spearman相关性分析结果显示：血清SDF‑1、MMP3、IL‑1β水平与L4/5、L5/S1节段腰椎间盘分级均呈正相关（分别为

=0.759、0.801、0.785和

=0.748、0.823、0.816；

0.05）。

结论

血清SDF‑1、MMP3、IL‑1β表达水平与腰椎间盘退变程度呈正相关，随着病情加重，其表达水平升高，提示血清血清SDF‑1、MMP3、IL‑1β水平与腰椎间盘退变的发生发展密切相关。

Abstract

Objective

To investigate the correlation between serum stromal cell⁃derived factor 1 (SDF‑1)

matrix metalloproteinase‑3 (MMP‑3)

interleukin‑1β （IL‑1β）

and the grade of intervertebral disc degeneration in patients with lumbar disc herniation（LDH）.

Methods

A total of 150 LDH patients admitted to our hospital from July 2020 to July 2022 were selected as the observation group

and another 90 healthy individuals with normal intervertebral disc tissue were selected as the healthy control group. The expression levels of serum SDF⁃1

MMP3

and IL⁃1β were compared between the two groups. The observation group was classified into Grade Ⅲ

Grade Ⅳ

and Grade Ⅴ of disc degeneration according to the Pfirrmann classification standard. The expression levels of serum SDF⁃1

MMP3

and IL⁃1β were compared among the different subgroups of disc herniation patients

respectively

at L4/5 and L5/S1 segments. Spearman's correlation analysis was performed to assess the relationship between the expression levels of serum SDF⁃1

MMP3

and IL⁃1β and the degeneration grade of intervertebral discs at L4/5 and L5/S1 segments.

Results

The levels of serum SDF‑1

MMP3

and IL‑1β in the observation group were higher than those in the control group (

0.05). Serum SDF‑1

MMP3

IL‑1β in different subgroups of patients with lumbar disc herniation at L4/5 and L5/S1 segments increased with the degree of lesion (

=68.867

47.578

212.079;

=221.461

346.920

514.849;

0.05). Spearman correlation analysis showed that the level of sserum SDF‑1

MMP3

and IL‑1β was positively correlated with L4/5 and L5/S1 lumbar disc classification (

=0.759

0.801

0.785;

0.748

0.823

0.816;

0.05).

Conclusion

The expression level of serum SDF‑1

MMP3

and IL‑1β was positively correlated with the degree of degeneration of the lumbar intervertebral disc. As the severity of the disease increases

their expression levels rise

suggesting a close association between serum levels of SDF⁃1

MMP3

and IL⁃1β and the development of lumbar disc degeneration.

关键词

Keywords

references

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