Research progress on biological control of bacterial wilt

GUO Jiayi; ZHANG Qingyun; XIANG Bikun; TAN Jun; QIAO Baoming; WANG Xuesong; ZHENG Shixue

doi:10.13300/j.cnki.hnlkxb.2025.05.016

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Research progress on biological control of bacterial wilt

Plant protection | 更新时间：2026-11-05

- Research progress on biological control of bacterial wilt
- Journal of Huazhong Agricultural University Vol. 44, Issue 5, Pages: 152-164(2025)
- 作者机构：
  
  1.华中农业大学生命科学技术学院/农业微生物资源发掘与利用全国重点实验室，武汉430070
  2.湖北省烟草公司恩施州公司，恩施445000
- 作者简介：
- 基金信息：
- DOI：10.13300/j.cnki.hnlkxb.2025.05.016
  CLC： S476
- Received：09 October 2024，
  
  Published：15 September 2025
- 稿件说明：
移动端阅览
郭佳怡，张晴云，向必坤，等.青枯病的生物防治研究进展［J］.华中农业大学学报，2025，44（5）：152‐164.

GUO Jiayi,ZHANG Qingyun,XIANG Bikun,et al.Research progress on biological control of bacterial wilt[J].Journal of Huazhong Agricultural University,2025,44(05):152-164.
郭佳怡，张晴云，向必坤，等.青枯病的生物防治研究进展［J］.华中农业大学学报，2025，44（5）：152‐164. DOI： 10.13300/j.cnki.hnlkxb.2025.05.016.

GUO Jiayi,ZHANG Qingyun,XIANG Bikun,et al.Research progress on biological control of bacterial wilt[J].Journal of Huazhong Agricultural University,2025,44(05):152-164. DOI： 10.13300/j.cnki.hnlkxb.2025.05.016.

摘要

青枯病是由茄科罗尔斯通氏菌（

Ralstonia solanacearum

）引起的细菌土传性病害。茄科罗尔斯通氏菌抗逆性强，传播途径广泛，而且变异快，存在多种变型，宿主范围广泛，因此，该菌引起的青枯病防治十分困难。生物防治具有绿

色安全、效果持久的特点，成为防控青枯病的重点方向。为厘清病原菌-植物宿主-生物防治策略间复杂的互作关系，促进青枯病防治的健康发展，本文主要从抗生素和没食子酸甲酯等生物代谢产物对茄科罗尔斯通氏菌的抑制作用、生防微生物对该菌的防控如细菌和真菌的拮抗作用和噬菌体特异性杀灭策略以及生态水平上通过调控微生物群落而抑制茄科罗尔斯通氏菌的过量繁殖与发病等方面综述近年来国内外生物防治青枯病的研究进展。此外，还讨论了生物防治面临的生防微生物活性、病原菌遗传变异复杂多样、复合病害频发以及生防制剂资源不足与经济成本高等多重挑战，并提出未来青枯病生物防治需通过合成微生物群落构建、噬菌体-益生元联用、合成生物学改造及综合管理策略，以提升防控效果和应用可持续性。

Abstract

Bacterial wilt，caused by

Ralstonia solanacearum

，is a soil-borne disease that poses significant challenges for control due to its strong stress resistance and diverse transmission pathways.Preventing and managing bacterial wilt is difficult because this pathogen evolves rapidly，and has a wide host range.Biological control，recognized as an eco-friendly and sustainable strategy，has emerged as a crucial approach for managing bacterial wilt.In order to clarify the complex interactions among pathogenic bacteria，plant hosts，and biocontrol strategies，and to promote the effective management of bacterial wilt，this article reviewed recent advances in the biocontrol of bacterial wilt from three aspects： the inhibitory effects of biological metabolites，such as antibiotics and methyl gallate，on

R. solanacearum

； the control of the pathogen by bacteria and fungi through antagonistic actions，as well as by bacteriophages employing specific lytic strategies； and the suppression of pathogen over-proliferation and disease manifestation at an ecological level through the regulation of microbial communities.Additionally，we discussed the multiple challenges of biocontrol，including microbial activity，the complex genetic diversity of pathogenic bacteria，the frequent occurrence of complex diseases，limited resources of biocontrol agents，and high economic costs.It was proposed that the future biocontrol of bacterial wilt should focus on improving control efficacy and application sustainability through the construction of synthetic microbial communities，phage-prebiotic combinations，synthetic biological transformations，an

d comprehensive management strategies.

关键词

Keywords

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