Function and molecular mechanism of the CFEM protein in plant pathogenic fungi

WANG Yanling; GUO Yong; GAO Jie

doi:10.13300/j.cnki.hnlkxb.2025.01.017

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Function and molecular mechanism of the CFEM protein in plant pathogenic fungi

Plant protection | 更新时间：2026-11-05

- Function and molecular mechanism of the CFEM protein in plant pathogenic fungi
- Journal of Huazhong Agricultural University Vol. 44, Issue 1, Pages: 156-167(2025)
- 作者机构：
  
  兰州理工大学生命科学与工程学院，兰州 730050
- 作者简介：
- 基金信息：
- DOI：10.13300/j.cnki.hnlkxb.2025.01.017
  CLC： S435
- Received：29 May 2024，
  
  Published：15 January 2025
- 稿件说明：
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王艳玲，郭勇，高洁.病原真菌CFEM蛋白功能及分子机制研究进展［J］.华中农业大学学报，2025，44（1）：156‐167.

WANG Yanling,GUO Yong,GAO Jie.Function and molecular mechanism of the CFEM protein in plant pathogenic fungi[J].Journal of Huazhong Agricultural University,2025,44(01):156-167.
王艳玲，郭勇，高洁.病原真菌CFEM蛋白功能及分子机制研究进展［J］.华中农业大学学报，2025，44（1）：156‐167. DOI： 10.13300/j.cnki.hnlkxb.2025.01.017.

WANG Yanling,GUO Yong,GAO Jie.Function and molecular mechanism of the CFEM protein in plant pathogenic fungi[J].Journal of Huazhong Agricultural University,2025,44(01):156-167. DOI： 10.13300/j.cnki.hnlkxb.2025.01.017.

摘要

CFEM （common in fungi extracellular membrane）蛋白是仅存在于真菌的一种细胞外膜蛋白，在真菌中往往起到效应子的作用。本文阐述了不同病原真菌CFEM蛋白的结构、起源、进化及其作用和分子机制，强调了致病性真菌中CFEM蛋白在获取铁元素、维护真菌细胞壁完整性、影响真菌生长发育、侵染结构形成及引发宿主免疫反应等方面的重要作用。同时对扩展青霉的CFEM蛋白进行生物信息学分析，并针对未来CFEM蛋白在侵染致病中的作用及分子机制等研究进行讨论和展望。旨在进一步解析CFEM蛋白在侵染致病中的作用和分子机理，为防控植物病原真菌病害提供理论基础和参考。

Abstract

The CFEM （common in fungi extracellular membrane） protein is an extracellular membrane protein that is unique to fungi and often founctions as an effector in various fungal species. This article elucidates the structure， origin， evolution， function， and molecular mechanisms of CFEM proteins across different pathogenic fungi. It highlights the critical roles of CFEM proteins in pathogenic fungi， including iron acquisition， maintenance of fungal cell wall integrity， influence on fungal growth and development， facilitation of infection structure formation， and elicitation of host immune responses. Additionally， a bioinformatic analysis of CFEM proteins in

Penicillium expansum

is presented. Future research directions on the roles and molecular mechanisms of CFEM proteins in fungal pathogenicity are also discussed. The aim is to enhance our understanding of the function and molecular mechanisms of CFEM proteins in fungal infection and pathogenesis， providing a theoretical foundation and reference for controlling plant fungal diseases.

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references

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