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目的采用功能性近红外光谱技术(fNIRS)观察脑卒中患者在执行运动-认知双任务时的脑血流动力学变化。方法募集符合标准的脑卒中患者36例
其中男18例
女18例
36例受试者采用简单随机法分别完成5项任务
包括单任务(分别为步行60 s和计算60 s)、顺序性双任务(步行30 s后再计算30 s和计算30 s后再步行30 s)和同时性双任务(步行与计算同步进行60 s)。使用fNIRS测量受试者完成5项任务时大脑皮质的脑血流动力学
并通过跑台收集受试者步行过程中的步态特征。结果 5项任务可诱发不同程度的大脑激活。功能性近红外结果显示
左、右侧前额叶和运动区在任务执行中均表现出显著的激活差异
单任务的激活水平显著低于顺序性双任务和同时性双任务(P<0.05)。在顺序性双任务中
先步行后计算任务的平均功能连接强度显著高于先计算后步行任务
差异有统计学意义(P<0.05)。步态分析结果显示
在单任务和顺序性双任务(先步行后计算)时的步速分别为(33.65±6.22)cm/s和(32.21±8.84)cm/s
均显著高于同时性双任务时的(24.37±10.33)cm/s(P<0.05)。结论慢性脑卒中患者在执行顺序性双任务和同时性双任务时
前额叶和运动皮质的激活程度均显著高于其执行单任务时
且任务难度和顺序的变化亦显著影响受试者的步态表现。
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