角膜塑形镜对儿童青少年低中度近视患者脉络膜结构和微循环的影响

龚奇; 余露润; 张灿灿; 鲁翼; 段欧文; 周炼红

doi:10.14188/j.1671-8852.2025.1298

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角膜塑形镜对儿童青少年低中度近视患者脉络膜结构和微循环的影响

更新时间：2026-11-03

- 角膜塑形镜对儿童青少年低中度近视患者脉络膜结构和微循环的影响
- The influence of orthokeratology lenses on the choroidal structure and microcirculation of adolescent patients with low to moderate myopia
- 武汉大学学报（医学版） 2026年页码：1-7
- 作者机构：
  
  武汉大学人民医院眼科中心湖北武汉 430060
- 作者简介：
  
  龚奇，男，2000—，医学硕士生，主要从事近视防控、儿童眼病的研究，E⁃mail:1181569613@qq.com。
  周炼红，E⁃mail:2935292648@qq.com。
- 基金信息：
  
  湖北省卫生健康委员会科研项目(WJ2023Z006);湖北省重点研发计划项目(2022BCA044);武汉大学人民医院交叉创新人才项目(JCRCGW⁃2022⁃007)
- DOI：10.14188/j.1671-8852.2025.1298
  中图分类号： R778.11
- 收稿：2025-11-03，
  
  网络首发：2026-11-03，
- 稿件说明：
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龚奇, 余露润, 张灿灿, 等. 角膜塑形镜对儿童青少年低中度近视患者脉络膜结构和微循环的影响[J/OL]. 武汉大学学报（医学版）, 2026,1-7.

GONG Qi, YU Lurun, ZHANG Cancan, et al. The influence of orthokeratology lenses on the choroidal structure and microcirculation of adolescent patients with low to moderate myopia[J/OL]. Medical Journal of Wuhan University, 2026, 1-7.
龚奇, 余露润, 张灿灿, 等. 角膜塑形镜对儿童青少年低中度近视患者脉络膜结构和微循环的影响[J/OL]. 武汉大学学报（医学版）, 2026,1-7. DOI： 10.14188/j.1671-8852.2025.1298.

GONG Qi, YU Lurun, ZHANG Cancan, et al. The influence of orthokeratology lenses on the choroidal structure and microcirculation of adolescent patients with low to moderate myopia[J/OL]. Medical Journal of Wuhan University, 2026, 1-7. DOI： 10.14188/j.1671-8852.2025.1298.

摘要

目的

探讨角膜塑形（OK）镜对低中度近视青少年脉络膜结构和微循环的影响，分析不同近视程度患者的响应差异。

方法

前瞻性纳入54例8~15岁低中度近视患者（低度近视组：-0.50 D≤SE

-3.00 D，

=31；中度近视组：-3.00 D≤SE

-6.00 D，

=23），监测戴镜1周、1月、3月、6月及1年后的眼轴长度（AL）及黄斑区9扇区（直径分别为1、3、6 mm的同心圆）的脉络膜厚度（ChT）与三维脉络膜血管指数（3D⁃CVI）变化，对比组间差异。

结果

两组患者各时间点AL增长量无显著差异（

0.05）。两组患者各时间点各区域ChT均增厚（

0.001），中度近视组ChT增厚量更高，两组患者均在外环颞侧（OT）的ChT变化量最大，外环鼻侧（ON）的脉络膜厚度变化量最小。两组患者各时间点各区域3D⁃CVI均提升（

0.001），但组间无差异，两组患者均在外环下方（OI）的3D⁃CVI变化量最大，中央凹（C）处的3D⁃CVI变化量最小。

结论

OK镜对低度近视和中度近视患者在AL和3D⁃CVI的变化量方面无显著差异，但在ChT变化量方面中度近视患者增厚量较低度近视患者多。

Abstract

Objective

To investigate the effects of orthokeratology （Ortho⁃K） on choroidal structure and microcirculation in adolescents with low to moderate myopia and to analyze response differences based on myopia severity.

Methods

This prospective study enrolled 54 adolescents （aged 8⁃15 years） with low to moderate myopia. Participants were divided into a low myopia group （spherical equivalent [SE

]

: -0.50 D to -3.00 D

=31） and a moderate myopia group （SE: -3.00 D to -6.00 D

=23）. Axial length （AL） and macular choroidal parameters

including choroidal thickness (ChT) and the three⁃dimensional choroidal vascularity index (3D⁃CVI)

were measured at baseline and after 1 week

1 month

3 months

6 months

and 1 year of Ortho⁃K lens wear. ChT and 3D⁃CVI were assessed within nine macular sectors defined by concentric circles of 1 mm

3 mm

and 6 mm diameter centered on the fovea. Intergroup differences were analyzed.

Results

The increase in AL over time showed no significant difference between the two groups at any follow⁃up point （

0.05）. Both groups exhibited a significant increase in ChT across all macular sectors and time points compared to baseline （

0.001）. The magnitude of ChT increase was significantly greater in the moderate myopia group than in the low myopia group. The greatest increase in ChT occurred in the outer temporal （OT） sector for both groups

while the smallest increase occurred in the outer nasal （ON） sector. 3D⁃CVI significantly increased from baseline in all sectors and at all time points for both groups （

0.001）. However

there was no significant difference in the magnitude of 3D⁃CVI increase between the two groups. The greatest increase in 3D⁃CVI occurred in the outer inferior （OI） sector for both groups

while the smallest increase occurred in the central foveal （C） sector.

Conclusion

Orthokeratology demonstrated comparable efficacy in controlling axial elongation and increasing 3D⁃CVI in adolescents with both low and moderate myopia. However

adolescents with moderate myopia exhibited a more pronounced increase in choroidal thickness compared to those with low myopia.

关键词

Keywords

references

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