Advances in understanding the mechanisms of isorhamnetin⁃mediated inhibition of malignant tumors

MA Wenjing; LIU Jingchun; LEI Wenkang; WU Xianjin; ZHAO Ruohan; ZHANG Jianyu; HU Min

doi:10.14188/j.1671-8852.2026.0735

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Advances in understanding the mechanisms of isorhamnetin⁃mediated inhibition of malignant tumors

更新时间：2026-11-03

- Advances in understanding the mechanisms of isorhamnetin⁃mediated inhibition of malignant tumors
- Medical Journal of Wuhan University Pages: 1-8(2026)
- 作者机构：
  
  1.武汉大学人民医院妇产科湖北武汉 430060
  2.武汉大学第一临床学院湖北武汉 430060
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2026.0735
  CLC： R285
- Received：08 May 2026，
  
  Online First：03 November 2026，
- 稿件说明：
移动端阅览
MA Wenjing, LIU Jingchun, LEI Wenkang, et al. Advances in understanding the mechanisms of isorhamnetin⁃mediated inhibition of malignant tumors[J/OL]. Medical Journal of Wuhan University, 2026, 1-8.
DOI：

MA Wenjing, LIU Jingchun, LEI Wenkang, et al. Advances in understanding the mechanisms of isorhamnetin⁃mediated inhibition of malignant tumors[J/OL]. Medical Journal of Wuhan University, 2026, 1-8. DOI： 10.14188/j.1671-8852.2026.0735.

摘要

恶性肿瘤是人类面临的重大健康问题之一，目前已有许多除手术外的治疗方法，如免疫疗法、基因治疗等。异鼠李素（ISO）是一种来源于植物的天然活性成分，已被证实具有抗炎、抗肿瘤、抗氧化的作用。本文聚焦于其抗肿瘤作用，从机制层面出发，系统阐述ISO通过调控PI3K/AKT、MAPK等信号通路，及诱导细胞凋亡、阻滞细胞周期、抑制上皮间质转化等途径，显著抑制肿瘤进展。此外，研究表明ISO能够与部分化疗药物协同作用，增强治疗效果。然而目前其临床应用仍面临诸多限制，如水溶性低、体内代谢迅速等问题，这些仍是未来研究需要突破的关键挑战。

Abstract

Malignant tumors are one of the major health problems facing humanity. Currently

there are many therapeutic methods besides surgery

such as immunotherapy and gene therapy. Isorhamnetin is a natural active ingredient derived from plants

which has been proven to possess anti⁃inflammatory

anti⁃tumor

and antioxidant properties. This article focuses on its anti⁃tumor effects and systematically elaborates on how isorhamnetin significantly inhibits tumor progression at the mechanistic level. It achieves this by regulating signaling pathways such as PI3K/AKT and MAPK

as well as through inducing cell apoptosis

arresting the cell cycle

and inhibiting the epithelial⁃mesenchymal transition process. Furthermore

studies have shown that isorhamnetin can synergize with some chemotherapeutic drugs to enhance therapeutic efficacy. However

its clinical application still faces numerous limitations

such as low water solubility and rapid metabolism

in vivo

which remain key challenges to be addressed in future research.

关键词

Keywords

references

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