The influence of orthokeratology lenses on the choroidal structure and microcirculation of adolescent patients with low to moderate myopia

GONG Qi; YU Lurun; ZHANG Cancan; LU Yi; DUAN Ouwen; ZHOU Lianghong

doi:10.14188/j.1671-8852.2025.1298

您当前的位置：

首页 >

文章列表页 >

The influence of orthokeratology lenses on the choroidal structure and microcirculation of adolescent patients with low to moderate myopia

更新时间：2026-11-03

- The influence of orthokeratology lenses on the choroidal structure and microcirculation of adolescent patients with low to moderate myopia
- Medical Journal of Wuhan University Pages: 1-7(2026)
- 作者机构：
  
  武汉大学人民医院眼科中心湖北武汉 430060
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2025.1298
  CLC： R778.11
- Received：03 November 2025，
  
  Online First：03 November 2026，
- 稿件说明：
移动端阅览
GONG Qi, YU Lurun, ZHANG Cancan, et al. The influence of orthokeratology lenses on the choroidal structure and microcirculation of adolescent patients with low to moderate myopia[J/OL]. Medical Journal of Wuhan University, 2026, 1-7.
DOI：

GONG Qi, YU Lurun, ZHANG Cancan, et al. The influence of orthokeratology lenses on the choroidal structure and microcirculation of adolescent patients with low to moderate myopia[J/OL]. Medical Journal of Wuhan University, 2026, 1-7. DOI： 10.14188/j.1671-8852.2025.1298.

摘要

目的

探讨角膜塑形（OK）镜对低中度近视青少年脉络膜结构和微循环的影响，分析不同近视程度患者的响应差异。

方法

前瞻性纳入54例8~15岁低中度近视患者（低度近视组：-0.50 D≤SE

-3.00 D，

=31；中度近视组：-3.00 D≤SE

-6.00 D，

=23），监测戴镜1周、1月、3月、6月及1年后的眼轴长度（AL）及黄斑区9扇区（直径分别为1、3、6 mm的同心圆）的脉络膜厚度（ChT）与三维脉络膜血管指数（3D⁃CVI）变化，对比组间差异。

结果

两组患者各时间点AL增长量无显著差异（

0.05）。两组患者各时间点各区域ChT均增厚（

0.001），中度近视组ChT增厚量更高，两组患者均在外环颞侧（OT）的ChT变化量最大，外环鼻侧（ON）的脉络膜厚度变化量最小。两组患者各时间点各区域3D⁃CVI均提升（

0.001），但组间无差异，两组患者均在外环下方（OI）的3D⁃CVI变化量最大，中央凹（C）处的3D⁃CVI变化量最小。

结论

OK镜对低度近视和中度近视患者在AL和3D⁃CVI的变化量方面无显著差异，但在ChT变化量方面中度近视患者增厚量较低度近视患者多。

Abstract

Objective

To investigate the effects of orthokeratology （Ortho⁃K） on choroidal structure and microcirculation in adolescents with low to moderate myopia and to analyze response differences based on myopia severity.

Methods

This prospective study enrolled 54 adolescents （aged 8⁃15 years） with low to moderate myopia. Participants were divided into a low myopia group （spherical equivalent [SE

]

: -0.50 D to -3.00 D

=31） and a moderate myopia group （SE: -3.00 D to -6.00 D

=23）. Axial length （AL） and macular choroidal parameters

including choroidal thickness (ChT) and the three⁃dimensional choroidal vascularity index (3D⁃CVI)

were measured at baseline and after 1 week

1 month

3 months

6 months

and 1 year of Ortho⁃K lens wear. ChT and 3D⁃CVI were assessed within nine macular sectors defined by concentric circles of 1 mm

3 mm

and 6 mm diameter centered on the fovea. Intergroup differences were analyzed.

Results

The increase in AL over time showed no significant difference between the two groups at any follow⁃up point （

0.05）. Both groups exhibited a significant increase in ChT across all macular sectors and time points compared to baseline （

0.001）. The magnitude of ChT increase was significantly greater in the moderate myopia group than in the low myopia group. The greatest increase in ChT occurred in the outer temporal （OT） sector for both groups

while the smallest increase occurred in the outer nasal （ON） sector. 3D⁃CVI significantly increased from baseline in all sectors and at all time points for both groups （

0.001）. However

there was no significant difference in the magnitude of 3D⁃CVI increase between the two groups. The greatest increase in 3D⁃CVI occurred in the outer inferior （OI） sector for both groups

while the smallest increase occurred in the central foveal （C） sector.

Conclusion

Orthokeratology demonstrated comparable efficacy in controlling axial elongation and increasing 3D⁃CVI in adolescents with both low and moderate myopia. However

adolescents with moderate myopia exhibited a more pronounced increase in choroidal thickness compared to those with low myopia.

关键词

Keywords

references

HOLDEN B A , FRICKE T R , WILSON D A , et al . Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050 [J ] . Ophthalmology , 2016 , 123 ( 5 ): 1036 ⁃ 1042 .

WU P C , HUANG H M , YU H J , et al . Epidemiology of myopia [J ] . Asia Pac J Ophthalmol (Phila) , 2016 , 5 ( 6 ): 386 ⁃ 393 .

MORGAN I G , FRENCH A N , ASHBY R S , et al . The epidemics of myopia: Aetiology and prevention [J ] . Prog Retin Eye Res , 2018 , 62 : 134 ⁃ 149 .

王会会 , 张晓红 , 霍俊锋 , 等 . 山西省四至六年级小学生近视现状及影响因素分析 [J ] . 中国健康教育 , 2022 , 38 ( 6 ): 483 ⁃ 486,490 .

WANG H H , ZHANG X H , HUO J F , et al . Prevalence and influencing factors of myopia among primary school students in grades four to six in Shanxi Province [J ] . Chinese Journal of Health Education , 2022 , 38 ( 6 ): 483 ⁃ 486, 490 .

唐仁香 , 程宇 , 郑小璐 , 等 . 角膜塑形镜控制青少年近视的机制研究进展 [J ] . 眼科新进展 , 2025 , 45 ( 5 ): 415 ⁃ 420 .

TANG R X , CHENG Y , ZHENG X L , et al . Research advance in the mechanisms of myopia control with orthokeratology in adolescent [J ] . Rec Adv Ophthalmol , 2025 , 45 ( 5 ): 415 ⁃ 420 .

隋金沅 , 李昊儒 , 林芳 , 等 . 近视防控措施干预下的脉络膜厚度与血流变化的研究进展 [J ] . 眼科新进展 , 2024 , 44 ( 11 ): 903 ⁃ 907 .

SUI J Y , LI H R , LIN F , et al . Research progress on changes in choroidal thickness and blood flow under myopia prevention and control interventions [J ] . Rec Adv Ophthalmol , 2024 , 44 ( 11 ): 903 ⁃ 907 .

童宇婷 , 马晓琪 , 周跃华 . 儿童青少年佩戴角膜塑形镜后不同时间点脉络膜厚度变化的Meta分析 [J ] . 中医眼耳鼻喉杂志 , 2023 , 13 ( 4 ): 185 ⁃ 189 .

TONG Y T , MA X Q , ZHOU Y H . Meta⁃analysis of choroidal thickness changes at different time points in children and adolescents after wearing orthokeratology lenses [J ] . J Chin Ophthalmol & Otorhinolaryngol , 2023 , 13 ( 4 ): 185 ⁃ 189 .

ZHU Q , ZHAO Q . Short⁃term effect of orthokeratology lens wear on choroidal blood flow in children with low and moderate myopia [J ] . Sci Rep , 2022 , 12 : 17653 .

WANG L , LIU Y , MA M , et al . Effects of orthokeratology lenses on choroidal thickness and choriocapillaris perfusion in myopic children [J ] . Front Med (Lausanne) , 2025 , 12 : 1620042 .

AI X , ZHANG X , WANG R , et al . Baseline ocular biometrics in children with orthokeratology⁃induced axial length reduction or elongation [J ] . BMC Ophthalmol , 2025 , 25 : 498 .

OSTRIN L A , SAH R P , QUEENER H M , et al . Short⁃term myopic defocus and choroidal thickness in children and adults [J ] . Invest Ophthalmol Vis Sci , 2024 , 65 ( 4 ): 22 .

WANG Z , CHEN J , KANG J , et al . Axial length control is associated with a choroidal thickness increase in myopic adolescents after orthokeratology [J ] . Eye Contact Lens , 2023 , 49 ( 12 ): 512 ⁃ 520 .

LI J , RONG B , ZHU L , et al . One⁃month changes in choroidal vascularity index of medium vessel layer in children with myopia wearing orthokeratology lenses: A predictor for one⁃year changes in axial length [J ] . Ophthalmol Ther , 2025 , 14 ( 10 ): 2395 ⁃ 2413 .

TAN B , CHUA J , WONG D . Techniques for imaging the choroid and choroidal blood flow in vivo [J ] . Exp Eye Res , 2024 , 247 : 110045 .

SPAIDE R F . Choroidal blood flow⁃venous anatomy and vortex system [J ] . Retina , 2020 , 40 : 1851 ⁃ 1864 .

DI PIPPO M , SANTIA C , RULLO D . The choroidal vascularity index versus optical coherence tomography angiography in the evaluation of the choroid with a focus on age⁃related macular degeneration [J ] . Tomography , 2023 , 9 : 1456 ⁃ 1470 .

MA F , BAI Y , DUAN J , et al . Validation of reliability, repeatability and consistency of three⁃dimensional choroidal vascular index [J ] . Sci Rep , 2024 , 14 : 1576 .

CHEONGK X , TEOK Y C , THAMY C . Three⁃dimensional modelling of the choroidal angioarchitecture in a multi⁃ethnic Asian population [J ] . Sci Rep , 2022 , 12 : 3831 .

ZENG Q , LUO L , YAO Y , et al . Three⁃dimensional choroidal vascularity index in central serous chorioretinopathy using ultra⁃widefield swept⁃source optical coherence tomography angiography [J ] . Front Med (Lausanne) , 2022 , 9 : 967369 .

CHEN Z , XUE F , ZHOU J , et al . Effects of orthokeratology on choroidal thickness and axial length [J ] . Optom Vis Sci , 2016 , 93 ( 9 ): 1064 ⁃ 1071 .

YANG Y , WEI L , WANG B , et al . Effects of atropine on choroidal thickness in myopic children: A meta⁃analysis [J ] . Front Pharmacol , 2024 , 15 : 1440180 .

WU H , PENG T , ZHOU W , et al . Choroidal vasculature act as predictive biomarkers of long⁃term ocular elongation in myopic children treated with orthokeratology: A prospective cohort study [J ] . Eye Vis (Lond) , 2023 , 10 ( 1 ): 27 .

魏宏宇 . 重复低能量红光治疗对近视儿童黄斑区脉络膜厚度及脉络膜毛细血管血流密度的影响研究 [D ] . 昆明 : 昆明医科大学 , 2023 .

WEI H Y . Low⁃level red⁃light therapy in myopic children improves choroid [D ] . Kunming : Kunming Medical University , 2023 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Application of swept‐source optical coherence tomography/optical coherence tomography angiography in evaluating macular retinal and choroidal parameters in school‐age children with various refractive errors

Research progress on compliance with spectacles among Chinese myopic children

Research and clinical application of multifocal soft contact lens

Correlation Analysis of Myopia Corneal Thickness and the Pressure Measurements

An Analysis of the Clinical Effect of Myopic Photorefractive Keratectomy After One Year’s Follow-up

Related Author

ZHANG Ying

QU Jie

WANG Man

WU Guohuan

WANG Shan

QIN Hui

ZHANG Qiao

LIU Haifang

Related Institution

Aier Eye Hospital of Wuhan University （Wuhan Aier Eye Hospital）

Dept. of Ophthalmology, Renmin Hospital of Wuhan University

Dept. of Ophthalmology, Ji'an Central People's Hospital

School of Nursing, Wuhan University

Eye Center， Renmin Hospital of Wuhan University

AI问答

⁰